Metallopeptide approach to the design of biologically active ligands: design of specific human neutrophil elastase inhibitors

Bioorg Med Chem Lett. 1999 May 17;9(10):1469-74. doi: 10.1016/s0960-894x(99)00217-6.

Abstract

A series of compounds was designed to inhibit human neutrophil elastase utilizing a modified metallopeptide scheme developed in our laboratory termed metal-ion induced distinctive array of structures (MIDAS). These metallopeptides, synthesized by solution and solid-phase methods, exhibited excellent structural diversity and specificity in inhibiting human neutrophil elastase.

MeSH terms

  • Binding Sites
  • Drug Design*
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Leukocyte Elastase / antagonists & inhibitors*
  • Metalloproteins / chemistry*
  • Peptides / chemistry*

Substances

  • Enzyme Inhibitors
  • Metalloproteins
  • Peptides
  • Leukocyte Elastase